Semantic locality-aware biclustering for brain functional network connectivity
BrainBiC is a novel deep biclustering framework that enhances the analysis of brain functional connectivity, particularly in schizophrenia. It addresses the challenges of subject heterogeneity by jointly stratifying subjects and features, enabling the discovery of meaningful connectivity patterns. The framework demonstrates superior performance in identifying distinct brain connectivity subgraphs that correlate with cognitive functions and clinical symptoms, thus advancing precision psychiatry. Extensive experiments across multiple neuroimaging datasets validate its effectiveness in capturing the complexities of brain dynamics.
In situ secondary structure imaging of protein phase separation and aggregation by hyperspectral stimulated Raman scattering microscopy
该研究开发了一种通过超光谱刺激拉曼散射显微镜成像蛋白质相分离和聚集的新技术，能够在活细胞中实现无标记的蛋白质结构成像。研究表明，该技术在神经退行性疾病的研究中具有重要应用潜力，能够提供关于蛋白质相分离及其转变的分子级信息。
BLVRA promotes glioblastoma progression by regulating fatty acid metabolism
本研究首次确认BLVRA在胶质母细胞瘤（GBM）中的关键作用，作为脂肪酸代谢的调节因子，BLVRA的表达与患者预后密切相关。通过整合转录组数据，研究揭示了BLVRA在维持脂质稳态和调节氧化应激中的重要性。BLVRA的缺失导致细胞增殖能力下降，并增加了对脂肪酸诱导的细胞毒性的敏感性，表明其可能成为GBM治疗的新靶点。
Direct circMAN1A2(2,3,4,5)-CENPB mRNA interaction regulates cell proliferation and cancer progression
研究发现circMAN1A2(2,3,4,5)在结直肠癌细胞增殖和肿瘤进展中发挥关键作用。该circRNA通过直接与CENPB mRNA相互作用，增强其稳定性，从而影响细胞增殖。研究表明，靶向circMAN1A2(2,3,4,5)的LNA能够有效抑制肿瘤生长，显示出其作为结直肠癌治疗靶点的潜力。这一发现为癌症治疗提供了新的思路和方向。
Repurposing resveratrol for redox-mediated inhibition of MTH1 in breast cancer
本研究揭示了白藜芦醇作为MTH1抑制剂的潜力，显示出显著的结合亲和力和抗癌效果。通过分子对接和体外实验，白藜芦醇在抑制乳腺癌细胞增殖方面表现出良好的效果，IC50值为18.13 ± 1.08 µM，且能诱导细胞凋亡。这些发现为白藜芦醇在乳腺癌治疗中的应用提供了理论基础，强调了其作为潜在抗癌药物的前景。
SETD5 in glioma cells conferred TRAIL resistance induction
SETD5 is identified as a key player in glioblastoma (GBM) resistance to TRAIL-induced apoptosis. The study reveals that SETD5 is significantly overexpressed in GBM, particularly in aggressive subtypes, and its knockdown enhances the efficacy of TRAIL treatment by promoting apoptotic pathways. This research highlights SETD5's potential as a therapeutic target to improve treatment outcomes for GBM patients, suggesting that targeting SETD5 may overcome TRAIL resistance and enhance therapeutic efficacy.
Molecular mechanisms of SLC30A10-mediated manganese transport
SLC30A10作为锰离子运输的关键转运蛋白，在维持细胞内锰离子平衡和保护神经细胞免受锰中毒方面发挥重要作用。研究通过高分辨率冷冻电镜技术揭示了其锰离子结合位点及运输机制，为锰中毒相关疾病的治疗提供了新的理论基础。
Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial
Tolododekin alfa, an IL-12 anchored drug conjugate, was evaluated in a Phase 1 trial involving patients with advanced solid tumors. The study demonstrated safety, with no dose-limiting toxicities, and a preliminary efficacy rate of 60% stable disease. The drug's design allows for local retention and immune activation within the tumor microenvironment, suggesting a promising approach for enhancing cancer immunotherapy. Further clinical development is warranted based on these findings.
Identification of a free-N-glycan with difucosylated type-1 lactosamine in cancerous tissue and its validation for cancer diagnosis by urinary testing
本研究识别出一种新型的糖链结构，名为difucosylated type-1 lactosamine，显示出在多种癌症患者尿液中的显著升高。这一发现为癌症的非侵入性诊断提供了新的生物标志物，尤其是在胃癌、结肠癌和胰腺癌等类型中。研究结果表明，这种糖链可能成为未来癌症检测的重要工具，具有较高的市场价值和临床应用潜力。
Adjuvant activity of a small molecule TLR4 agonist discovered via structure-based virtual screening
NSF-951, identified through structure-based virtual screening, is a small molecule TLR4 agonist with significant immunostimulatory properties. It enhances antigen-specific immune responses in mice without notable toxicity, making it a promising candidate for vaccine adjuvants. The study highlights its potential applications in both veterinary and human vaccines, emphasizing its cost-effectiveness and ease of synthesis compared to traditional adjuvants like MPLA.
Neuron-reactive KIR+CD8+ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis
本研究揭示了自体反应性CD8+ T细胞在自身免疫性脑炎（AIE）中的关键作用，特别是在Ri-AIE患者中的表现。通过开发一种新方法，研究人员能够识别神经反应性CD8+ T细胞，并分析其转录组特征，发现这些细胞在Ri-AIE患者中表现出增强的活化和细胞毒性特征。这一发现为理解AIE的发病机制提供了新的视角，并可能为未来的治疗策略提供依据。
Dexamethasone-loaded platelet-inspired nanoparticles improve intracortical microelectrode recording performance
研究表明，负载地塞米松的血小板启发纳米颗粒（DEXSPPIN）能够显著改善脑内微电极（IME）的记录性能，减少插入引起的神经炎症和神经元损失。通过靶向药物递送，DEXSPPIN不仅提高了记录的稳定性，还促进了血脑屏障的修复，显示出其在神经科学和脑机接口应用中的潜力。
Post-resection delivery of a TLR7/8 agonist from a biodegradable scaffold achieves immune-mediated glioblastoma clearance and protection against tumor challenge in mice
研究表明，生物降解支架局部释放TLR7/8激动剂在胶质母细胞瘤手术切除后能有效清除残余肿瘤，并提高小鼠的生存率。该方法通过增强局部免疫反应，促进了抗肿瘤免疫记忆的形成，展示了其在胶质母细胞瘤治疗中的潜力，具有重要的临床应用前景和投资价值。
The histone methyltransferase SETD2 regulates adult brain structure, connectivity and neurogenesis
SETD2是一种组蛋白甲基转移酶，对成年大脑的结构、连接性和神经发生具有重要调节作用。研究发现，SETD2缺失会导致成年小鼠大脑体积显著减少，尤其是在海马体区域，影响神经干细胞的增殖和新生神经元的生成。这些发现为理解SETD2在神经发育中的角色提供了重要基础，并可能对相关神经发育障碍的治疗具有潜在的临床意义。
T817MA protects against inflammation and pyroptosis in response to brain ischemia via activating Sirt1 signaling
T817MA是一种新型神经保护剂，通过激活Sirt1信号通路，抑制缺血性脑损伤中的神经炎症和细胞焦亡，显示出良好的治疗潜力。研究结果表明，T817MA能够改善缺血后大鼠的神经功能，减少脑水肿，具有作为缺血性中风治疗药物的前景。