Revealing the protective potential of D-(-)-Quinic acid against thioacetamide-induced hepatic encephalopathy in rats
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来源：
Nature
发布时间：
2025-08-26 15:32
摘要：
D-(-)-Quinic acid (D-(-)-QA) exhibits protective effects against thioacetamide-induced hepatic encephalopathy (HE) in rats by mitigating inflammation and oxidative stress. The study reveals that D-(-)-QA significantly reduces serum ammonia levels and improves liver function markers, while also suppressing proinflammatory cytokines such as TNF-α and IL-1β. The findings suggest that D-(-)-QA could serve as a promising therapeutic candidate for treating HE, highlighting its potential in addressing liver dysfunction through modulation of the PI3K/AKT signaling pathway.
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关键证据
D-(-)-QA significantly prevented the increase in ammonia levels and improved liver function.
Treatment with D-(-)-QA suppressed proinflammatory cytokines and oxidative damage.
D-(-)-QA may be an alternative to current clinical interventions for hepatic encephalopathy.
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AI评分总结
D-(-)-Quinic acid (D-(-)-QA) exhibits protective effects against thioacetamide-induced hepatic encephalopathy (HE) in rats by mitigating inflammation and oxidative stress. The study reveals that D-(-)-QA significantly reduces serum ammonia levels and improves liver function markers, while also suppressing proinflammatory cytokines such as TNF-α and IL-1β. The findings suggest that D-(-)-QA could serve as a promising therapeutic candidate for treating HE, highlighting its potential in addressing liver dysfunction through modulation of the PI3K/AKT signaling pathway.