Design of multi-target peptide modulators for protein chaperone networks
8.4
来源：
Cell
发布时间：
2025-08-26 16:03
摘要：
Cdk4-2 is a multi-target peptide modulator designed to inhibit the chaperones Hsp70 and Hsp90, which are crucial in cancer cell survival. This peptide has shown efficacy in inducing apoptosis in renal carcinoma cells and represents a novel approach in cancer therapy by targeting multiple protein interactions. The research highlights the potential for developing rationally designed compounds that can disrupt oncogenic protein networks, paving the way for innovative cancer treatments.
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关键证据
Cdk4-2 shows promising anti-cancer effects.
Peptide Cdk4-2 binds Hsp70 and Hsp90, inducing apoptosis.
The design demonstrates feasibility for multi-target modulators.
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AI评分总结
Cdk4-2 is a multi-target peptide modulator designed to inhibit the chaperones Hsp70 and Hsp90, which are crucial in cancer cell survival. This peptide has shown efficacy in inducing apoptosis in renal carcinoma cells and represents a novel approach in cancer therapy by targeting multiple protein interactions. The research highlights the potential for developing rationally designed compounds that can disrupt oncogenic protein networks, paving the way for innovative cancer treatments.