Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection
8.0
来源：
Cell
发布时间：
2025-08-27 03:34
摘要：
This study investigates the structural basis of poxvirus fusion regulation and the neutralization potential of antibodies targeting the A16/G9 complex. Findings indicate that A16/G9 can elicit protective immune responses in mice against vaccinia virus (VACV), positioning it as a candidate for subunit vaccines. The research highlights the urgent need for novel antiviral strategies against monkeypox, especially given its recent classification as a public health emergency. The structural insights gained may facilitate the development of effective therapeutics targeting the viral entry-fusion complex.
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domain_focus
1.0
business_impact
1.0
scientific_rigor
1.5
timeliness_innovation
1.5
investment_perspective
2.5
market_value_relevance
1.0
team_institution_background
0.5
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0.5
关键证据
Immunization with A16/G9 elicited a protective immune response in mice.
The study provides structural insights into the A16/G9 complex and its interaction with viral proteins.
A16/G9 may serve as a candidate for subunit vaccines and antiviral development.
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AI评分总结
This study investigates the structural basis of poxvirus fusion regulation and the neutralization potential of antibodies targeting the A16/G9 complex. Findings indicate that A16/G9 can elicit protective immune responses in mice against vaccinia virus (VACV), positioning it as a candidate for subunit vaccines. The research highlights the urgent need for novel antiviral strategies against monkeypox, especially given its recent classification as a public health emergency. The structural insights gained may facilitate the development of effective therapeutics targeting the viral entry-fusion complex.