Tumor-derived PRMT1 suppresses macrophage antitumor activity by inhibiting cGAS/STING signaling in gastric cancer cells
8.5
来源：
Nature
发布时间：
2025-08-27 03:46
摘要：
PRMT1, an epigenetic regulator, is found to suppress macrophage antitumor activity in gastric cancer by inhibiting the cGAS/STING signaling pathway. Its knockdown promotes M1 macrophage polarization and enhances the antitumor immune response, indicating its potential as a therapeutic target in gastric cancer treatment.
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关键证据
PRMT1 knockdown leads to increased infiltration of M1-like macrophages.
Activation of cGAS/STING signaling enhances antitumor immunity.
PRMT1 is associated with poor prognosis in gastric cancer patients.
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AI评分总结
PRMT1, an epigenetic regulator, is found to suppress macrophage antitumor activity in gastric cancer by inhibiting the cGAS/STING signaling pathway. Its knockdown promotes M1 macrophage polarization and enhances the antitumor immune response, indicating its potential as a therapeutic target in gastric cancer treatment.