Capilliposide A attenuates diabetic nephropathy via modulation of NF-κB/TLR4 and apoptotic pathways
8.5
来源：
Nature
发布时间：
2025-08-27 07:55
摘要：
Capilliposide A (LC-A) shows promise as a nephroprotective agent against diabetic nephropathy (DN) by modulating key inflammatory pathways. The study utilized a diabetic mouse model to demonstrate LC-A's efficacy in reducing renal injury markers and improving metabolic indices. Network pharmacology identified critical targets such as TLR4 and NF-κB1, while molecular docking confirmed LC-A's binding affinity to these proteins. With the increasing prevalence of diabetes, LC-A's potential therapeutic role in DN presents significant clinical and commercial implications.
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关键证据
LC-A significantly reduced renal injury markers (KI, SCR, BUN) and improved metabolic indices.
Network pharmacology identified TLR4, NF-κB1 as core targets involved in inflammation regulation.
Molecular docking confirmed stable binding of LC-A to key inflammatory pathway proteins.
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AI评分总结
Capilliposide A (LC-A) shows promise as a nephroprotective agent against diabetic nephropathy (DN) by modulating key inflammatory pathways. The study utilized a diabetic mouse model to demonstrate LC-A's efficacy in reducing renal injury markers and improving metabolic indices. Network pharmacology identified critical targets such as TLR4 and NF-κB1, while molecular docking confirmed LC-A's binding affinity to these proteins. With the increasing prevalence of diabetes, LC-A's potential therapeutic role in DN presents significant clinical and commercial implications.