The role and clinical value of natriuretic peptide receptor family in malignant tumor
8.0
来源：
Nature
发布时间：
2025-08-28 15:31
摘要：
Natriuretic peptide receptors (NPRs) exhibit distinct roles in cancer biology, with NPRA functioning as an oncogenic driver linked to poor prognosis in various malignancies, while NPRC acts as a tumor suppressor. The article discusses their mechanisms, including angiogenesis and metastasis, and highlights their potential as biomarkers and therapeutic targets. Engineered ligands targeting NPRs demonstrate promising efficacy in preclinical models, suggesting a new direction for cancer treatment. Future research should focus on their dual functions and the development of targeted therapies.
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1.0分+核心领域符合度
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1.0分+具有商业影响力
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1.5分+有具体实验数据支持
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2.5分+早期研发阶段
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0.5分+团队背景良好
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关键证据
NPRA is overexpressed in multiple cancers, activating oncogenic pathways.
NPRC consistently acts as a tumor suppressor across multiple cancers.
Engineered ligands targeting NPRs show promising antitumor efficacy.
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AI评分总结
Natriuretic peptide receptors (NPRs) exhibit distinct roles in cancer biology, with NPRA functioning as an oncogenic driver linked to poor prognosis in various malignancies, while NPRC acts as a tumor suppressor. The article discusses their mechanisms, including angiogenesis and metastasis, and highlights their potential as biomarkers and therapeutic targets. Engineered ligands targeting NPRs demonstrate promising efficacy in preclinical models, suggesting a new direction for cancer treatment. Future research should focus on their dual functions and the development of targeted therapies.