UPP1 is a dual biomarker of prognosis and immune microenvironment in IDH wild-type glioblastoma
8.4
来源：
Nature
发布时间：
2025-08-28 15:32
摘要：
UPP1 has been identified as a dual biomarker in IDH wild-type glioblastoma, correlating with poor patient prognosis and influencing the immune microenvironment. High UPP1 expression is linked to increased immune cell infiltration and immunosuppression, suggesting its potential as a therapeutic target. The study highlights UPP1's role in tumor progression and immune evasion, emphasizing the need for further exploration of its mechanisms and therapeutic implications.
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关键证据
UPP1 overexpression correlated with poor survival (P < 0.05).
Silencing UPP1 suppressed proliferation (P < 0.001) in glioma cells.
UPP1 serves as a promising target for GBM precision therapy.
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AI评分总结
UPP1 has been identified as a dual biomarker in IDH wild-type glioblastoma, correlating with poor patient prognosis and influencing the immune microenvironment. High UPP1 expression is linked to increased immune cell infiltration and immunosuppression, suggesting its potential as a therapeutic target. The study highlights UPP1's role in tumor progression and immune evasion, emphasizing the need for further exploration of its mechanisms and therapeutic implications.