The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease
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来源：
Nature
发布时间：
2025-08-28 19:35
摘要：
The unfolded protein response (UPR) is crucial for maintaining bone homeostasis and has significant implications in cancer-associated bone disease, particularly in multiple myeloma and metastatic cancers. This article reviews the role of UPR signaling in bone biology, its connection to cancer development, and discusses various UPR modulators that may serve as therapeutic targets. The findings suggest that targeting UPR pathways could provide dual benefits in treating cancer and restoring bone health.
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关键证据
The unfolded protein response has been found to promote oncogenesis and drug resistance.
Understanding the critical role of UPR signaling in cancer development and metastasis may lead to novel therapeutic strategies.
UPR modulators have demonstrated potential bone-related benefits in vivo.
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AI评分总结
The unfolded protein response (UPR) is crucial for maintaining bone homeostasis and has significant implications in cancer-associated bone disease, particularly in multiple myeloma and metastatic cancers. This article reviews the role of UPR signaling in bone biology, its connection to cancer development, and discusses various UPR modulators that may serve as therapeutic targets. The findings suggest that targeting UPR pathways could provide dual benefits in treating cancer and restoring bone health.