Selenized neural stem cell-derived exosomes: A neotype therapeutic agent for traumatic injuries of the central nervous system
8.4
来源：
Cell
发布时间：
2025-08-29 03:31
摘要：
SeNExo, a novel therapeutic agent developed from neural stem cell-derived exosomes, shows significant promise for treating traumatic injuries of the central nervous system (CNS). By functionalizing exosomes with ultrasmall nano-selenium, SeNExo enhances reactive oxygen species (ROS) scavenging and effectively penetrates the blood-brain barrier. In murine models of traumatic brain injury (TBI) and spinal cord injury (SCI), SeNExo significantly improves cognitive and locomotor functions, highlighting its potential as a new treatment strategy for CNS injuries.
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关键证据
SeNExo exhibits ROS scavenging and neuroprotection abilities.
Therapeutic efficacies are demonstrated in TBI and SCI model mice.
SeNExo penetrates the blood-brain barrier via APOE_LRP-1 interaction.
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AI评分总结
SeNExo, a novel therapeutic agent developed from neural stem cell-derived exosomes, shows significant promise for treating traumatic injuries of the central nervous system (CNS). By functionalizing exosomes with ultrasmall nano-selenium, SeNExo enhances reactive oxygen species (ROS) scavenging and effectively penetrates the blood-brain barrier. In murine models of traumatic brain injury (TBI) and spinal cord injury (SCI), SeNExo significantly improves cognitive and locomotor functions, highlighting its potential as a new treatment strategy for CNS injuries.