Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution
8.3
来源：
Cell
发布时间：
2025-08-29 03:31
摘要：
Stereo-seq V2 represents a breakthrough in spatial transcriptomics, allowing for high-resolution mapping of total RNA on formalin-fixed, paraffin-embedded (FFPE) samples. This innovative technology utilizes random primers for unbiased RNA capture, enhancing sensitivity and efficiency in profiling both host and pathogen transcriptomes. The method has shown robust performance in clinical applications, particularly in analyzing triple-negative breast cancer samples, and holds promise for advancing personalized medicine and infectious disease research.
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关键证据
Stereo-seq V2 enables total RNA spatial mapping in FFPE samples.
The random-priming-based strategy offers unbiased transcript capturing and uniform gene body coverage.
Demonstrated robust performance on clinical FFPE samples using triple-negative breast cancer sections.
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AI评分总结
Stereo-seq V2 represents a breakthrough in spatial transcriptomics, allowing for high-resolution mapping of total RNA on formalin-fixed, paraffin-embedded (FFPE) samples. This innovative technology utilizes random primers for unbiased RNA capture, enhancing sensitivity and efficiency in profiling both host and pathogen transcriptomes. The method has shown robust performance in clinical applications, particularly in analyzing triple-negative breast cancer samples, and holds promise for advancing personalized medicine and infectious disease research.