NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization
8.4
来源：
Nature
发布时间：
2025-08-29 19:33
摘要：
NEXN has been identified as a crucial modulator in vascular calcification, interacting with SERCA2 to enhance its SUMOylation and stability. This interaction mitigates the phenotypic transition of vascular smooth muscle cells, which is pivotal in the development of vascular calcification. The findings suggest that targeting NEXN-SERCA2 interactions could provide novel therapeutic strategies for preventing vascular calcification and its associated cardiovascular complications.
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关键证据
NEXN interacts with SERCA2, enhancing its SUMOylation and stability.
NEXN deficiency exacerbates vascular calcification in models.
Overexpression of NEXN alleviates calcification, indicating therapeutic potential.
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AI评分总结
NEXN has been identified as a crucial modulator in vascular calcification, interacting with SERCA2 to enhance its SUMOylation and stability. This interaction mitigates the phenotypic transition of vascular smooth muscle cells, which is pivotal in the development of vascular calcification. The findings suggest that targeting NEXN-SERCA2 interactions could provide novel therapeutic strategies for preventing vascular calcification and its associated cardiovascular complications.