OTUB2/NR4A1 restrains the development of preeclampsia by suppressing macrophage M1 polarization
7.5
来源：
Nature
发布时间：
2025-08-29 23:38
摘要：
OTUB2, a deubiquitinase, is found to be downregulated in preeclamptic placentas. Its overexpression suppresses M1 macrophage polarization, alleviating preeclampsia-like symptoms in experimental models. The study suggests OTUB2's potential as a therapeutic target for preeclampsia, providing insights into its role in macrophage function and trophoblast invasion, which are critical for successful pregnancy outcomes.
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关键证据
OTUB2 was downregulated in placenta from preeclampsia patients.
OTUB2 overexpression blocked M1 polarization of macrophages.
OTUB2 alleviated LPS-induced preeclampsia-like symptoms in rats.
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OTUB2, a deubiquitinase, is found to be downregulated in preeclamptic placentas. Its overexpression suppresses M1 macrophage polarization, alleviating preeclampsia-like symptoms in experimental models. The study suggests OTUB2's potential as a therapeutic target for preeclampsia, providing insights into its role in macrophage function and trophoblast invasion, which are critical for successful pregnancy outcomes.