Histamine as a mediator of cross-talk between human lung mast cells and macrophages
7.0
来源：
Nature
发布时间：
2025-08-30 19:34
摘要：
Histamine plays a crucial role in the activation of human lung macrophages, inducing the release of pro-inflammatory cytokines such as IL-6, TNF-α, and IL-1β. The study reveals that histamine's effects are mediated through the H1 receptor, with implications for asthma and allergic diseases. Additionally, histamine promotes reactive oxygen species production and alters macrophage chemotaxis and kinetic properties, suggesting its involvement in chronic inflammatory lung disorders.
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关键证据
Histamine induces the release of pro-inflammatory cytokines from human lung macrophages.
The study shows histamine's role in activating macrophages, relevant for asthma.
Findings suggest potential therapeutic implications for allergic diseases.
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AI评分总结
Histamine plays a crucial role in the activation of human lung macrophages, inducing the release of pro-inflammatory cytokines such as IL-6, TNF-α, and IL-1β. The study reveals that histamine's effects are mediated through the H1 receptor, with implications for asthma and allergic diseases. Additionally, histamine promotes reactive oxygen species production and alters macrophage chemotaxis and kinetic properties, suggesting its involvement in chronic inflammatory lung disorders.