WEE1 inhibitor exerts synergistic effect with KRAS G12C inhibitor via MYBL2-RRM2 axis in KRASG12C-mutant lung cancer
9.0
来源：
Nature
发布时间：
2025-08-31 03:39
摘要：
The study reveals that the combination of WEE1 inhibitors and KRAS G12C inhibitors exerts a synergistic effect in KRAS G12C-mutant lung cancer, primarily through the MYBL2-RRM2 axis. This combination enhances anti-tumor efficacy while minimizing toxicity, presenting a promising therapeutic strategy for lung cancer treatment. The findings suggest potential investment opportunities in innovative cancer therapies targeting this pathway.
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1.5分+1.5
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1.5分+1.5
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2.5分+2.5
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关键证据
Combination therapy significantly inhibited tumor growth in KRAS G12C mutant lung cancer models.
MYBL2-RRM2 axis identified as a key mechanism for the observed synergistic effects.
Research supports the potential for clinical application of combined therapies.
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AI评分总结
The study reveals that the combination of WEE1 inhibitors and KRAS G12C inhibitors exerts a synergistic effect in KRAS G12C-mutant lung cancer, primarily through the MYBL2-RRM2 axis. This combination enhances anti-tumor efficacy while minimizing toxicity, presenting a promising therapeutic strategy for lung cancer treatment. The findings suggest potential investment opportunities in innovative cancer therapies targeting this pathway.