In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID
7.0
来源：
Nature
发布时间：
2025-08-31 07:43
摘要：
The research introduces innovative proximity biotinylation methods using AirID to validate protein interactions, particularly focusing on PROTACs like ARV-110 for prostate cancer treatment. The study highlights the importance of E3 ligase selection in drug development, revealing how different E3 ligases can affect the interaction profiles of target proteins. This work contributes to the understanding of drug mechanisms and the potential for developing effective therapies in oncology.
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关键证据
ARV-110 is an oral PROTAC that targets the androgen receptor in clinical trials.
The study presents a novel proximity biotinylation method for analyzing drug-induced protein interactions.
The findings suggest significant implications for the development of targeted therapies in oncology.
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AI评分总结
The research introduces innovative proximity biotinylation methods using AirID to validate protein interactions, particularly focusing on PROTACs like ARV-110 for prostate cancer treatment. The study highlights the importance of E3 ligase selection in drug development, revealing how different E3 ligases can affect the interaction profiles of target proteins. This work contributes to the understanding of drug mechanisms and the potential for developing effective therapies in oncology.