m6A and cardiac posttranscriptional regulation: a novel player in heart development and disease
8.0
来源：
Nature
发布时间：
2025-09-01 11:33
摘要：
m6A modifications are crucial in cardiac biology, influencing gene expression and cellular behavior in heart development and disease. This review highlights the regulatory roles of m6A in cardiomyocyte differentiation, proliferation, and associated pathologies, including heart failure and congenital heart defects. The findings suggest that targeting m6A pathways may offer new therapeutic strategies for cardiovascular diseases, emphasizing the need for further research in this area.
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关键证据
m6A modifications are critical for maintaining cardiac function and are linked to various cardiovascular diseases.
The review identifies knowledge gaps in the role of m6A in heart development, suggesting future research directions.
Emerging evidence links aberrant m6A regulation to congenital heart defects, indicating its potential as a therapeutic target.
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AI评分总结
m6A modifications are crucial in cardiac biology, influencing gene expression and cellular behavior in heart development and disease. This review highlights the regulatory roles of m6A in cardiomyocyte differentiation, proliferation, and associated pathologies, including heart failure and congenital heart defects. The findings suggest that targeting m6A pathways may offer new therapeutic strategies for cardiovascular diseases, emphasizing the need for further research in this area.