YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer
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来源：
Nature
发布时间：
2025-09-01 15:34
摘要：
USP43 is a deubiquitinating enzyme that plays a significant role in ovarian cancer by promoting tumor growth and resistance to ferroptosis. The study reveals that USP43 stabilizes FASN, which in turn activates HIF1α and SLC7A11, contributing to the malignant phenotype of ovarian cancer cells. This research underscores the potential of targeting USP43 in combination with cisplatin to improve treatment outcomes for patients with ovarian cancer.
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关键证据
USP43 is overexpressed in ovarian cancer and correlates with poor prognosis.
USP43 regulates ferroptosis through the FASN-HIF1α-SLC7A11 axis.
Targeting USP43 may enhance the efficacy of platinum-based therapies.
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AI评分总结
USP43 is a deubiquitinating enzyme that plays a significant role in ovarian cancer by promoting tumor growth and resistance to ferroptosis. The study reveals that USP43 stabilizes FASN, which in turn activates HIF1α and SLC7A11, contributing to the malignant phenotype of ovarian cancer cells. This research underscores the potential of targeting USP43 in combination with cisplatin to improve treatment outcomes for patients with ovarian cancer.