Uncovering novel functions of NUF2 in glioblastoma and MRI-based expression prediction
9.5
来源：
Nature
发布时间：
2025-09-01 19:47
摘要：
NUF2 is identified as a critical oncogene in glioblastoma multiforme (GBM), with its elevated expression linked to poor patient outcomes. This study explores NUF2's mechanisms in GBM progression and presents a novel MRI-based machine learning model for predicting NUF2 expression, achieving an AUC of 0.897. The findings suggest that targeting NUF2 could enhance therapeutic strategies for GBM, emphasizing its role as a potential biomarker for personalized treatment approaches.
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关键证据
NUF2 overexpression in GBM tissues correlates with poor survival (p < 0.01).
Developed a predictive model using MRI with an AUC of 0.897.
NUF2 knockdown significantly suppressed malignant phenotypes in GBM cells.
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AI评分总结
NUF2 is identified as a critical oncogene in glioblastoma multiforme (GBM), with its elevated expression linked to poor patient outcomes. This study explores NUF2's mechanisms in GBM progression and presents a novel MRI-based machine learning model for predicting NUF2 expression, achieving an AUC of 0.897. The findings suggest that targeting NUF2 could enhance therapeutic strategies for GBM, emphasizing its role as a potential biomarker for personalized treatment approaches.