Astaxanthin mitigates cardiac toxicity induced via doxorubicin by alleviating mitochondrial fission and autophagy in rats
8.0
来源：
Nature
发布时间：
2025-09-01 23:37
摘要：
Astaxanthin (ASTA) demonstrates cardioprotective effects against doxorubicin (DOX)-induced cardiac toxicity in a rat model. The study reveals that ASTA mitigates mitochondrial damage by regulating mitochondrial dynamics and autophagy, improving cardiac function and reducing myocardial injury. These findings suggest ASTA's potential as a therapeutic agent in oncology, particularly in enhancing the safety of chemotherapy regimens involving DOX.
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1.0
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1.5
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关键证据
ASTA alleviates DOX-induced cardiac mitochondrial damage.
ASTA regulates mitochondrial dynamics and autophagy.
ASTA shows promise as a prospective drug for cardiac protection.
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AI评分总结
Astaxanthin (ASTA) demonstrates cardioprotective effects against doxorubicin (DOX)-induced cardiac toxicity in a rat model. The study reveals that ASTA mitigates mitochondrial damage by regulating mitochondrial dynamics and autophagy, improving cardiac function and reducing myocardial injury. These findings suggest ASTA's potential as a therapeutic agent in oncology, particularly in enhancing the safety of chemotherapy regimens involving DOX.