Klotho protein alleviates heart ischemia/reperfusion injury and oxidative stress through regulation of the NOS/MMP pathway
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来源：
Nature
发布时间：
2025-09-02 19:32
摘要：
Klotho protein demonstrates significant cardioprotective effects against heart ischemia/reperfusion injury by mitigating oxidative and nitrosative stress through the regulation of the NOS/MMP signaling pathway. This study utilized both in vitro human cardiomyocyte cultures and ex vivo isolated rat hearts, revealing Klotho's potential as a therapeutic target for cardiovascular diseases. The findings suggest that Klotho could play a crucial role in improving heart function and recovery post-injury, highlighting its importance in managing ischemic heart conditions.
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关键证据
Klotho significantly improved heart mechanical and contractile function following ischemia/reperfusion.
The study utilized in vitro human cardiomyocyte culture and ex vivo isolated rat hearts.
Klotho regulated MMP-2 and MMP-9 synthesis and activity, protecting heart contractile proteins from degradation.
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AI评分总结
Klotho protein demonstrates significant cardioprotective effects against heart ischemia/reperfusion injury by mitigating oxidative and nitrosative stress through the regulation of the NOS/MMP signaling pathway. This study utilized both in vitro human cardiomyocyte cultures and ex vivo isolated rat hearts, revealing Klotho's potential as a therapeutic target for cardiovascular diseases. The findings suggest that Klotho could play a crucial role in improving heart function and recovery post-injury, highlighting its importance in managing ischemic heart conditions.