Echinacea purpurea ameliorates Bleomycin-induced pulmonary fibrosis in rats through modulating NADPH oxidase-4 and endothelin-1/connective tissue growth factor/matrix metalloproteinases signalling axis
7.3
来源：
Nature
发布时间：
2025-09-03 03:36
摘要：
Echinacea purpurea has been shown to ameliorate Bleomycin-induced pulmonary fibrosis in rats through modulation of oxidative stress and inflammatory pathways. The study indicates that Echinacea treatment significantly reduces markers of fibrosis and oxidative damage, suggesting its potential as a therapeutic agent for pulmonary fibrosis. This research highlights the need for further investigations to explore the clinical applicability of Echinacea in treating lung diseases.
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关键证据
ECH treatment significantly reduced lung tissue contents of MDA, TGF-β, MMP-2, MMP-9, and TIMP-1.
The study suggests Echinacea as a potential therapy for pulmonary fibrosis.
Echinacea modulated key signaling pathways involved in fibrosis.
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AI评分总结
Echinacea purpurea has been shown to ameliorate Bleomycin-induced pulmonary fibrosis in rats through modulation of oxidative stress and inflammatory pathways. The study indicates that Echinacea treatment significantly reduces markers of fibrosis and oxidative damage, suggesting its potential as a therapeutic agent for pulmonary fibrosis. This research highlights the need for further investigations to explore the clinical applicability of Echinacea in treating lung diseases.