EBAMP: An efficient de novo broad-spectrum antimicrobial peptide discovery framework
8.0
来源：
Cell
关键字：
neural coding
发布时间：
2025-09-03 23:30
摘要：
EBAMP is a novel framework for the de novo design of broad-spectrum antimicrobial peptides, effectively addressing the challenges posed by multidrug-resistant bacteria and fungi. The study reports the generation of 256 peptides, with 96 exhibiting significant antimicrobial activity. In vivo testing of the peptide bsa001 showed comparable efficacy to existing antibiotics, highlighting its potential as a new therapeutic option. This innovative approach combines generative and discriminative methods, paving the way for future advancements in antimicrobial peptide research and development.
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关键证据
The study generated 256 antimicrobial peptides, with 37.5% showing effective antimicrobial activity.
In vivo tests demonstrated that the peptide bsa001 effectively inhibited multidrug-resistant bacteria and fungi.
The framework addresses the urgent need for new antimicrobial strategies in light of rising drug resistance.
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AI评分总结
EBAMP is a novel framework for the de novo design of broad-spectrum antimicrobial peptides, effectively addressing the challenges posed by multidrug-resistant bacteria and fungi. The study reports the generation of 256 peptides, with 96 exhibiting significant antimicrobial activity. In vivo testing of the peptide bsa001 showed comparable efficacy to existing antibiotics, highlighting its potential as a new therapeutic option. This innovative approach combines generative and discriminative methods, paving the way for future advancements in antimicrobial peptide research and development.