Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models
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来源：
Nature
关键字：
ML brain science
发布时间：
2025-09-04 23:32
摘要：
PA-915, a PAC1 receptor antagonist, exhibits rapid and long-lasting antidepressant effects in chronic stress mouse models, improving anxiety-like behaviors and cognitive dysfunction without inducing adverse effects. This study highlights the potential of PA-915 as a promising treatment for stress-related disorders, addressing the limitations of current therapies.
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关键证据
PA-915 significantly suppresses anxiety-like behavior in chronic stress-induced mice.
A single dose of PA-915 shows antidepressant-like effects lasting for at least 8 weeks.
PA-915 does not induce behavioral abnormalities in non-stressed mice.
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AI评分总结
PA-915, a PAC1 receptor antagonist, exhibits rapid and long-lasting antidepressant effects in chronic stress mouse models, improving anxiety-like behaviors and cognitive dysfunction without inducing adverse effects. This study highlights the potential of PA-915 as a promising treatment for stress-related disorders, addressing the limitations of current therapies.