Mucus-inspired hydrogels with protonation-driven adhesion for extreme acidic conditions
8.4
来源：
Cell
关键字：
neuromodulation
发布时间：
2025-09-05 03:30
摘要：
UMIH (ultrastable mucus-inspired hydrogel) exhibits remarkable adhesion and stability in extreme acidic conditions, achieving a wet adhesion strength of 64.7 kPa at pH 2. Its innovative design utilizes high-isoelectric-point proteins and tannic acid to enhance adhesion and structural integrity. In vivo studies demonstrate its potential for gastrointestinal tissue repair, showing significant improvements in epithelial regeneration and reduced inflammation. The UMIH's multifunctional capabilities, including antimicrobial properties, position it as a promising solution for gastrointestinal applications and targeted drug delivery.
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关键证据
UMIH achieves a wet adhesion strength of 64.7 kPa at pH 2, surpassing existing hydrogels.
In vivo studies confirm UMIH's effectiveness in promoting tissue healing and adhesion.
The hydrogel's design incorporates high-isoelectric-point proteins for enhanced performance.
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AI评分总结
UMIH (ultrastable mucus-inspired hydrogel) exhibits remarkable adhesion and stability in extreme acidic conditions, achieving a wet adhesion strength of 64.7 kPa at pH 2. Its innovative design utilizes high-isoelectric-point proteins and tannic acid to enhance adhesion and structural integrity. In vivo studies demonstrate its potential for gastrointestinal tissue repair, showing significant improvements in epithelial regeneration and reduced inflammation. The UMIH's multifunctional capabilities, including antimicrobial properties, position it as a promising solution for gastrointestinal applications and targeted drug delivery.