An HIV fusion-inhibitory lipopeptide provides robust post-exposure prophylaxis and prevents viral reservoir seeding in macaques
8.5
来源：
Cell
关键字：
AI brain science
发布时间：
2025-09-09 03:34
摘要：
LP-98, an HIV fusion-inhibitory lipopeptide, has shown significant efficacy in preventing SHIVSF162P3 infection and viral reservoir seeding in rhesus macaques. The study highlights its pharmacokinetics, achieving a half-life of approximately 31 hours, and demonstrates robust post-exposure prophylaxis when administered early. The findings suggest that LP-98 could play a crucial role in HIV prevention and treatment strategies, with potential implications for clinical applications. The research underscores the importance of early intervention in limiting viral spread and establishing effective therapeutic regimens.
原文：
查看原文
价值分投票
评分标准
新闻价值分采用0-10分制，综合考虑新闻的真实性、重要性、时效性、影响力等多个维度。
评分越高，表示该新闻的价值越大，越值得关注。
价值维度分析
domain_focus
1.0分
business_impact
1.0分
scientific_rigor
1.5分
timeliness_innovation
1.5分
investment_perspective
2.5分
market_value_relevance
1.0分
team_institution_background
0.5分
technical_barrier_competition
0.5分
关键证据
LP-98 provided robust protection against SHIVSF162P3 infection.
No viral DNA or replication-competent virus was detected in tissues from protected RMs.
LP-98 achieved a T1/2 of ∼31 h and maintained therapeutic concentration for up to 2 weeks post-injection.
真实性检查
否
AI评分总结
LP-98, an HIV fusion-inhibitory lipopeptide, has shown significant efficacy in preventing SHIVSF162P3 infection and viral reservoir seeding in rhesus macaques. The study highlights its pharmacokinetics, achieving a half-life of approximately 31 hours, and demonstrates robust post-exposure prophylaxis when administered early. The findings suggest that LP-98 could play a crucial role in HIV prevention and treatment strategies, with potential implications for clinical applications. The research underscores the importance of early intervention in limiting viral spread and establishing effective therapeutic regimens.