The mesocorticolimbic system in stimulant use disorder
7.5
来源：
Nature
关键字：
computational pathology
发布时间：
2025-09-10 15:32
摘要：
The article reviews the role of the mesocorticolimbic system in Stimulant Use Disorder (StUD), emphasizing the urgent need for effective treatments due to the absence of approved medications. It discusses the neurochemical mechanisms involved in stimulant use and highlights significant gaps in current research, suggesting that understanding these processes could guide the development of novel therapeutic interventions. The review underscores the global increase in stimulant use and overdose deaths, reinforcing the importance of addressing StUD through innovative approaches.
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关键证据
Stimulant Use Disorder (StUD) is a pervasive and extremely dangerous form of addiction for which there are currently no approved medications.
A deeper understanding of the mechanisms driving the initiation and persistence of stimulant use is critical for developing more effective interventions.
Emerging evidence points to neurochemical processes and neural circuitry within the mesocorticolimbic (MCL) system.
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AI评分总结
The article reviews the role of the mesocorticolimbic system in Stimulant Use Disorder (StUD), emphasizing the urgent need for effective treatments due to the absence of approved medications. It discusses the neurochemical mechanisms involved in stimulant use and highlights significant gaps in current research, suggesting that understanding these processes could guide the development of novel therapeutic interventions. The review underscores the global increase in stimulant use and overdose deaths, reinforcing the importance of addressing StUD through innovative approaches.