CD38 connects the heart and brain
7.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-09-11 19:34
摘要：
CD38 is a transmembrane glycoprotein that plays a vital role in both cardiovascular and neurological health. This review highlights its involvement in heart-brain diseases, discussing mechanisms of action and potential therapeutic targets. Recent findings suggest that inhibiting CD38 may alleviate conditions such as heart failure and depression, making it a promising target for future drug development. The article emphasizes the need for further research to explore CD38's dual role and its implications for treatment strategies in cardiovascular and neurological disorders.
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domain_focus
1.0
business_impact
1.0
scientific_rigor
1.5
timeliness_innovation
1.5
investment_perspective
2.5
market_value_relevance
1.0
team_institution_background
0.5
technical_barrier_competition
0.5
关键证据
CD38 is implicated in the shared pathogenesis of heart-brain diseases.
Inhibition of CD38 has shown potential to alleviate pathological processes related to cardiovascular and neurological disorders.
Recent studies indicate that CD38 inhibitors may improve outcomes in heart failure and depression.
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AI评分总结
CD38 is a transmembrane glycoprotein that plays a vital role in both cardiovascular and neurological health. This review highlights its involvement in heart-brain diseases, discussing mechanisms of action and potential therapeutic targets. Recent findings suggest that inhibiting CD38 may alleviate conditions such as heart failure and depression, making it a promising target for future drug development. The article emphasizes the need for further research to explore CD38's dual role and its implications for treatment strategies in cardiovascular and neurological disorders.