Lead binds HIF-1α contributing to depression-like behaviour through modulating mitochondria-associated astrocyte ferroptosis
7.5
来源：
Nature
关键字：
ML brain science
发布时间：
2025-09-11 23:32
摘要：
Lead exposure has been linked to increased incidence of depression, with this study demonstrating that it induces depression-like behaviors in mice through ferroptosis in astrocytes. The research identifies HIF-1α as a critical regulator, suggesting that Pb stabilizes HIF-1α, promoting mitochondrial dysfunction and ferroptosis. These findings provide insights into the neurobiological mechanisms underlying Pb-induced depression, highlighting potential therapeutic targets for intervention.
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关键证据
Lead exposure induces depression-like behaviors in mice.
Ferroptosis is implicated in the mechanism of depression due to Pb exposure.
HIF-1α is identified as a key regulator in astrocyte ferroptosis.
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AI评分总结
Lead exposure has been linked to increased incidence of depression, with this study demonstrating that it induces depression-like behaviors in mice through ferroptosis in astrocytes. The research identifies HIF-1α as a critical regulator, suggesting that Pb stabilizes HIF-1α, promoting mitochondrial dysfunction and ferroptosis. These findings provide insights into the neurobiological mechanisms underlying Pb-induced depression, highlighting potential therapeutic targets for intervention.