Cryo-EM structure of the full-length LGR4-RSPOs complex and a targeting nanobody for anti-obesity therapy
8.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-09-25 23:41
摘要：
This research elucidates the cryo-EM structures of the LGR4-RSPOs complex and introduces a novel nanobody, NB21, aimed at combating obesity. The study demonstrates that NB21-mFc effectively inhibits RSPO1/2 binding to LGR4, enhancing thermogenesis and promoting weight loss in various obesity models. These findings underscore the potential of LGR4 as a therapeutic target and pave the way for innovative anti-obesity treatments.
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关键证据
The study successfully resolves the cryo-EM structure of full-length LGR4 and its complex with RSPO2.
NB21-mFc significantly promotes thermogenesis and weight loss in both diet-induced and genetically obese mice.
The findings provide a novel therapeutic approach targeting LGR4, a promising candidate in obesity treatment.
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AI评分总结
This research elucidates the cryo-EM structures of the LGR4-RSPOs complex and introduces a novel nanobody, NB21, aimed at combating obesity. The study demonstrates that NB21-mFc effectively inhibits RSPO1/2 binding to LGR4, enhancing thermogenesis and promoting weight loss in various obesity models. These findings underscore the potential of LGR4 as a therapeutic target and pave the way for innovative anti-obesity treatments.