Characterization of the effects of oxymatrine on myocardial hypertrophy in spontaneously hypertensive rats through transcriptomics and metabolomics

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来源： Nature 关键字： mRNA

发布时间： 2025-09-26 03:47

摘要：

Oxymatrine (OMT), an alkaloid from traditional Chinese medicine, shows promise in treating myocardial hypertrophy in spontaneously hypertensive rats. The study employs transcriptomics and metabolomics to elucidate the mechanisms by which OMT alleviates cardiac hypertrophy, revealing its effects on gene expression and metabolic pathways. Key findings include the reversal of hypertrophy-associated gene expression and metabolite levels, indicating OMT's potential as a therapeutic agent for cardiovascular diseases.

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关键证据

OMT significantly alleviates myocardial hypertrophy and improves myocardial remodeling in spontaneously hypertensive rats.

Transcriptomic analysis revealed that OMT reversed the expression of genes associated with metabolic pathways.

Metabolomic analysis indicated that OMT reversed the levels of metabolites related to steroid hormone biosynthesis.

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AI评分总结

Oxymatrine (OMT), an alkaloid from traditional Chinese medicine, shows promise in treating myocardial hypertrophy in spontaneously hypertensive rats. The study employs transcriptomics and metabolomics to elucidate the mechanisms by which OMT alleviates cardiac hypertrophy, revealing its effects on gene expression and metabolic pathways. Key findings include the reversal of hypertrophy-associated gene expression and metabolite levels, indicating OMT's potential as a therapeutic agent for cardiovascular diseases.