Murraya koenigii methanolic extract inhibits bacterial growth and biofilm of Staphylococcus aureus and Enterococcus faecalis
8.0
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-01 03:43
摘要：
Murraya koenigii methanolic extract (MKM) exhibits significant antibacterial activity against Staphylococcus aureus and Enterococcus faecalis, with minimum inhibitory concentrations of 39 µg/mL and 48.8 µg/mL, respectively. The extract disrupts biofilm formation and reduces extracellular polymeric substance production, indicating its potential as a novel therapeutic agent against biofilm-associated infections. Molecular docking studies reveal strong binding affinities of MKM-derived compounds with key biofilm-related proteins, suggesting a promising avenue for combating antibiotic resistance.
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关键证据
MKM extract effectively inhibited the growth of S. aureus and E. faecalis at their respective MIC levels.
Flow cytometry and confocal imaging demonstrated substantial membrane damage in MKM-treated cells.
MKM extract significantly disrupts biofilm formation and reduces extracellular polymeric substance production.
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AI评分总结
Murraya koenigii methanolic extract (MKM) exhibits significant antibacterial activity against Staphylococcus aureus and Enterococcus faecalis, with minimum inhibitory concentrations of 39 µg/mL and 48.8 µg/mL, respectively. The extract disrupts biofilm formation and reduces extracellular polymeric substance production, indicating its potential as a novel therapeutic agent against biofilm-associated infections. Molecular docking studies reveal strong binding affinities of MKM-derived compounds with key biofilm-related proteins, suggesting a promising avenue for combating antibiotic resistance.