Garcinone D mitigates amyloid β42-Induced neurotoxicity: unravelling mechanisms of neuroprotection
9.5
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-01 03:44
摘要：
Garcinone D, a bioactive xanthone from mangosteen, exhibits significant neuroprotective effects against amyloid β42-induced neurotoxicity in SH-SY5Y cells. The study reveals that GD enhances cell viability, stabilizes mitochondrial function, and activates antioxidant pathways while inhibiting apoptotic markers. These findings suggest GD's potential as a therapeutic candidate for Alzheimer's disease, addressing multiple aspects of cellular damage associated with neurodegeneration. Further research is warranted to explore its therapeutic applications.
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关键证据
Garcinone D significantly enhances cell viability and stabilizes mitochondrial function.
GD activates key antioxidant pathways involving Nrf2 and HO-1, and inhibits caspase activity.
The study suggests GD could serve as a valuable therapeutic candidate for Alzheimer's disease.
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AI评分总结
Garcinone D, a bioactive xanthone from mangosteen, exhibits significant neuroprotective effects against amyloid β42-induced neurotoxicity in SH-SY5Y cells. The study reveals that GD enhances cell viability, stabilizes mitochondrial function, and activates antioxidant pathways while inhibiting apoptotic markers. These findings suggest GD's potential as a therapeutic candidate for Alzheimer's disease, addressing multiple aspects of cellular damage associated with neurodegeneration. Further research is warranted to explore its therapeutic applications.