Adiponectin receptor agonist, AdipoRon, restores hepatic clock gene expression in PCOS-associated NAFLD
7.0
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-01 03:45
摘要：
AdipoRon, an adiponectin receptor agonist, has shown promising results in restoring hepatic clock gene expression and improving metabolic dysfunction in a PCOS-associated NAFLD rat model. The study highlights its potential therapeutic benefits, including alleviating insulin resistance and lipid accumulation, which are critical in managing PCOS-related complications. These findings suggest that AdipoRon could be a valuable candidate for further development in treating metabolic disorders linked to PCOS.
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关键证据
AdipoRon improved metabolic profiles and liver function in PCOS-induced NAFLD models.
Study shows AdipoRon modulates hepatic circadian gene expression epigenetically.
Significant reduction in liver enzyme levels and improvement in insulin sensitivity were observed.
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AI评分总结
AdipoRon, an adiponectin receptor agonist, has shown promising results in restoring hepatic clock gene expression and improving metabolic dysfunction in a PCOS-associated NAFLD rat model. The study highlights its potential therapeutic benefits, including alleviating insulin resistance and lipid accumulation, which are critical in managing PCOS-related complications. These findings suggest that AdipoRon could be a valuable candidate for further development in treating metabolic disorders linked to PCOS.