Vitamin B17 alleviates Sorafenib-induced cardiotoxicity in Ehrlich Ascites Carcinoma mice via modulation of inflammatory and fibrotic pathways
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来源：
Nature
关键字：
mRNA
发布时间：
2025-10-01 04:04
摘要：
Vitamin B17 (VB17) has been shown to alleviate Sorafenib-induced cardiotoxicity in a mouse model of Ehrlich Ascites Carcinoma (EAC) by modulating inflammatory and fibrotic pathways. The study found that the combination therapy significantly reduced tumor volume and improved cardiac function, evidenced by normalized cardiac enzyme levels and reduced oxidative stress markers. Gene expression analysis indicated that VB17 enhances the cardioprotective effects of Sorafenib by regulating key pathways involved in inflammation and apoptosis. These findings suggest a promising strategy for improving the cardiac health of cancer patients undergoing chemotherapy.
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关键证据
Combination therapy significantly reduced tumor burden and improved cardiac function.
VB17 co-treatment lowered elevated troponin I levels and normalized cardiac enzyme levels.
Gene analysis showed reduced expression of pro-inflammatory markers and enhanced P53 expression.
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AI评分总结
Vitamin B17 (VB17) has been shown to alleviate Sorafenib-induced cardiotoxicity in a mouse model of Ehrlich Ascites Carcinoma (EAC) by modulating inflammatory and fibrotic pathways. The study found that the combination therapy significantly reduced tumor volume and improved cardiac function, evidenced by normalized cardiac enzyme levels and reduced oxidative stress markers. Gene expression analysis indicated that VB17 enhances the cardioprotective effects of Sorafenib by regulating key pathways involved in inflammation and apoptosis. These findings suggest a promising strategy for improving the cardiac health of cancer patients undergoing chemotherapy.