MAP4K signaling pathways in cancer: roles, mechanisms and therapeutic opportunities
8.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-01 19:36
摘要：
MAP4K family kinases are crucial regulators in cancer, influencing tumorigenesis, metastasis, and immune responses. This review highlights their potential as therapeutic targets, discussing specific inhibitors and the dual roles of these kinases in various cancers. The findings underscore the need for targeted therapies and the development of MAP4K-specific inhibitors, paving the way for novel cancer treatment strategies.
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关键证据
MAP4K family kinases are implicated in tumor growth, metastasis, and immune modulation.
Targeting MAP4K kinases presents a promising therapeutic strategy in oncology.
The review highlights the dual roles of MAP4K kinases as oncogenes and tumor suppressors.
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AI评分总结
MAP4K family kinases are crucial regulators in cancer, influencing tumorigenesis, metastasis, and immune responses. This review highlights their potential as therapeutic targets, discussing specific inhibitors and the dual roles of these kinases in various cancers. The findings underscore the need for targeted therapies and the development of MAP4K-specific inhibitors, paving the way for novel cancer treatment strategies.