Exploration of isolated actives from Coleus amboinicus leaves as anticancer agents: in vitro testing, network pharmacology studies, and molecular docking
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来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-02 23:37
摘要：
The isolated compound 16-hydroxy-7α-acetoxyroyleanone from Coleus amboinicus exhibits significant cytotoxic activity against various cancer cell lines, particularly MCF-7 and Du-145, with lower IC50 values than standard chemotherapy agents like cisplatin. Network pharmacology studies reveal its interaction with critical proteins in cancer pathways, suggesting its potential as a novel anticancer drug. The findings support further research into its therapeutic applications, particularly for breast and prostate cancers.
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关键证据
The compound showed lower IC50 values against cancer cells compared to cisplatin.
Network pharmacology studies identified key proteins targeted by the compound.
The study indicates the compound's potential for further development as an anticancer agent.
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AI评分总结
The isolated compound 16-hydroxy-7α-acetoxyroyleanone from Coleus amboinicus exhibits significant cytotoxic activity against various cancer cell lines, particularly MCF-7 and Du-145, with lower IC50 values than standard chemotherapy agents like cisplatin. Network pharmacology studies reveal its interaction with critical proteins in cancer pathways, suggesting its potential as a novel anticancer drug. The findings support further research into its therapeutic applications, particularly for breast and prostate cancers.