Ceftriaxone suppresses the severity of paclitaxel-induced glutamate-mediated chronic pain in experimental animals
8.0
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-03 23:38
摘要：
Ceftriaxone has been shown to alleviate paclitaxel-induced neuropathic pain in a rat model by enhancing glutamate transporter expression and reuptake, thereby reducing excitotoxicity. The study emphasizes the importance of glutamate regulation in chronic pain mechanisms and suggests ceftriaxone as a promising candidate for therapeutic strategies in managing neuropathic pain.
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关键证据
Ceftriaxone treatment significantly increased pain thresholds.
Ceftriaxone enhances glutamate reuptake and reduces excitotoxicity.
Study highlights the potential role of glutamate regulation in chronic pain mechanisms.
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AI评分总结
Ceftriaxone has been shown to alleviate paclitaxel-induced neuropathic pain in a rat model by enhancing glutamate transporter expression and reuptake, thereby reducing excitotoxicity. The study emphasizes the importance of glutamate regulation in chronic pain mechanisms and suggests ceftriaxone as a promising candidate for therapeutic strategies in managing neuropathic pain.