Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq
7.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-03 23:52
摘要：
The research presents scTF-seq, a novel technique for examining how transcription factor doses influence cell reprogramming heterogeneity. By analyzing mouse embryonic multipotent stromal cells, the study uncovers critical insights into lineage specification and the interplay between transcription factors and cell cycle dynamics. This work has significant implications for stem cell biology and potential applications in regenerative medicine.
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domain_focus
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0.5
scientific_rigor
1.5
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关键证据
The study developed a single-cell transcription factor sequencing (scTF-seq) technique.
It identifies key regulators of lineage specification and cell cycle control.
The findings reveal how TF dose shapes reprogramming heterogeneity.
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AI评分总结
The research presents scTF-seq, a novel technique for examining how transcription factor doses influence cell reprogramming heterogeneity. By analyzing mouse embryonic multipotent stromal cells, the study uncovers critical insights into lineage specification and the interplay between transcription factors and cell cycle dynamics. This work has significant implications for stem cell biology and potential applications in regenerative medicine.