The IGF2BP3–FASN axis drives lipid metabolic reprogramming to promote brain colonization in non-small cell lung cancer
8.5
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-06 19:33
摘要：
This study elucidates the role of the IGF2BP3-FASN axis in promoting brain colonization of non-small cell lung cancer (NSCLC) cells through lipid metabolic reprogramming. Elevated IGF2BP3 expression in NSCLC brain metastases correlates with poor prognosis, and its knockdown reduces cell proliferation, migration, and invasion. The findings suggest that targeting IGF2BP3 may provide a novel therapeutic strategy for NSCLC brain metastasis by disrupting lipid metabolism.
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1.5分
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2.5分
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关键证据
IGF2BP3 is upregulated in NSCLC brain metastases and correlates with poor prognosis.
The IGF2BP3-FASN axis is identified as a critical regulator of lipid metabolism.
Targeting IGF2BP3 significantly inhibits NSCLC cell growth in the brain microenvironment.
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AI评分总结
This study elucidates the role of the IGF2BP3-FASN axis in promoting brain colonization of non-small cell lung cancer (NSCLC) cells through lipid metabolic reprogramming. Elevated IGF2BP3 expression in NSCLC brain metastases correlates with poor prognosis, and its knockdown reduces cell proliferation, migration, and invasion. The findings suggest that targeting IGF2BP3 may provide a novel therapeutic strategy for NSCLC brain metastasis by disrupting lipid metabolism.