NY-ESO-1 facilitates anoikis resistance and tumor metastasis by hijacking deubiquitinase OTUB1 to stabilize PP1α
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-06 19:38
摘要：
NY-ESO-1 plays a significant role in promoting anoikis resistance and tumor metastasis by stabilizing PP1α through its interaction with the deubiquitinase OTUB1. This mechanism enhances ERK1/2 activation, contributing to poor patient prognosis, particularly in immune-cold tumors. The findings suggest that targeting NY-ESO-1 could provide a novel therapeutic strategy for preventing tumor metastasis, expanding treatment options for patients with NY-ESO-1-positive tumors.
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关键证据
NY-ESO-1 is crucial for anoikis resistance and tumor metastasis.
The study establishes a novel signaling axis involving NY-ESO-1, OTUB1, and PP1α.
High NY-ESO-1 expression correlates with poor prognosis in cancer patients.
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AI评分总结
NY-ESO-1 plays a significant role in promoting anoikis resistance and tumor metastasis by stabilizing PP1α through its interaction with the deubiquitinase OTUB1. This mechanism enhances ERK1/2 activation, contributing to poor patient prognosis, particularly in immune-cold tumors. The findings suggest that targeting NY-ESO-1 could provide a novel therapeutic strategy for preventing tumor metastasis, expanding treatment options for patients with NY-ESO-1-positive tumors.