Aloesin activates Nrf2 signaling to attenuate obesity-associated oxidative stress and hepatic steatosis in high-fat diet-fed rats
8.3
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-08 03:44
摘要：
Aloesin, a compound derived from Aloe vera, has shown promising hepatoprotective effects against non-alcoholic fatty liver disease (NAFLD) in a rat model induced by a high-fat diet. The study highlights its ability to activate Nrf2 signaling, which mitigates oxidative stress and inflammation, leading to improved metabolic parameters and liver health. These findings suggest that aloesin could be a valuable therapeutic agent for NAFLD, warranting further exploration in clinical settings.
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关键证据
Aloesin significantly reduced body and liver weights in HFD rats.
The study confirmed Nrf2 pathway involvement in aloesin's protective effects.
Aloesin improved metabolic profiles and liver histology in treated rats.
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AI评分总结
Aloesin, a compound derived from Aloe vera, has shown promising hepatoprotective effects against non-alcoholic fatty liver disease (NAFLD) in a rat model induced by a high-fat diet. The study highlights its ability to activate Nrf2 signaling, which mitigates oxidative stress and inflammation, leading to improved metabolic parameters and liver health. These findings suggest that aloesin could be a valuable therapeutic agent for NAFLD, warranting further exploration in clinical settings.