Sensitive, high-throughput, metabolic analysis by molecular sensors on the membrane surface of mother yeast cells
8.0
来源：
Nature
关键字：
CRISPR
发布时间：
2025-10-08 03:51
摘要：
MOMS (molecular sensors on the membrane surface of mother yeast cells) is a groundbreaking system designed for high-throughput metabolic analysis of yeast. It allows for ultrasensitive detection of extracellular secretions, achieving a detection limit of 100 nM and screening rates of over 3,000 cells per second. This innovative platform significantly enhances the efficiency of identifying high-performing yeast strains for biomanufacturing applications, demonstrating a more than 30-fold increase in processing speed compared to traditional methods.
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关键证据
MOMS achieves a > 30-fold speed boost compared to conventional droplet-based screening.
The platform offers potential for large-scale single-yeast metabolic analysis and bio-fabrication.
MOMS enables the identification of top secretory strains from extensive mutant libraries in about 12 minutes.
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AI评分总结
MOMS (molecular sensors on the membrane surface of mother yeast cells) is a groundbreaking system designed for high-throughput metabolic analysis of yeast. It allows for ultrasensitive detection of extracellular secretions, achieving a detection limit of 100 nM and screening rates of over 3,000 cells per second. This innovative platform significantly enhances the efficiency of identifying high-performing yeast strains for biomanufacturing applications, demonstrating a more than 30-fold increase in processing speed compared to traditional methods.