Baicalin alleviates H2O2-induced oxidative stress injury in human umbilical vein endothelial cells by regulating the TNF- α -mediated MAPK/ERK1/2/MPO pathway
7.5
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-08 23:40
摘要：
Baicalin, a flavonoid from traditional Chinese medicine, shows promise in protecting human umbilical vein endothelial cells from oxidative stress, a key factor in preeclampsia. The study reveals that baicalin regulates the TNF-α-mediated MAPK/ERK1/2 pathway, highlighting its potential as a therapeutic agent. Results indicate that baicalin can significantly reduce apoptosis and restore myeloperoxidase levels, suggesting a dual role in oxidative stress modulation. These findings pave the way for further research and potential clinical applications in managing preeclampsia.
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关键证据
Baicalin effectively restored MPO secretion levels and reduced apoptosis.
The study identifies the MAPK/ERK1/2 pathway as a central mechanism.
Baicalin's protective effects are comparable to TNF-α antagonists.
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AI评分总结
Baicalin, a flavonoid from traditional Chinese medicine, shows promise in protecting human umbilical vein endothelial cells from oxidative stress, a key factor in preeclampsia. The study reveals that baicalin regulates the TNF-α-mediated MAPK/ERK1/2 pathway, highlighting its potential as a therapeutic agent. Results indicate that baicalin can significantly reduce apoptosis and restore myeloperoxidase levels, suggesting a dual role in oxidative stress modulation. These findings pave the way for further research and potential clinical applications in managing preeclampsia.