Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer
10.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-08 23:52
摘要：
Kisspeptin-10 has been shown to exert multifaceted anti-tumor effects in triple-negative breast cancer (TNBC) cells, including suppression of cell proliferation, inhibition of migration, and activation of apoptosis pathways. The study highlights its potential as a therapeutic candidate by restoring KISS1 expression and modulating key molecular pathways involved in tumor progression. These findings underscore the importance of Kisspeptin-10 in addressing the challenges posed by aggressive breast cancer subtypes.
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1.5分+1.5
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关键证据
Kisspeptin-10 treatment significantly reduced cell viability and migration.
Kisspeptin-10 modulates key transcription factors and apoptotic pathways.
The study proposes Kisspeptin-10 as a potential therapeutic candidate for TNBC.
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AI评分总结
Kisspeptin-10 has been shown to exert multifaceted anti-tumor effects in triple-negative breast cancer (TNBC) cells, including suppression of cell proliferation, inhibition of migration, and activation of apoptosis pathways. The study highlights its potential as a therapeutic candidate by restoring KISS1 expression and modulating key molecular pathways involved in tumor progression. These findings underscore the importance of Kisspeptin-10 in addressing the challenges posed by aggressive breast cancer subtypes.