Lactococcus lactis subsp. cremoris C60 promotes immunoglobulin a production from B cells through functional modification of dendritic cells in the intestinal environment
7.5
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-10 03:42
摘要：
Lactococcus lactis subsp. cremoris C60 is identified as a novel probiotic strain that enhances immunoglobulin A (IgA) production by modulating dendritic cells in the intestinal environment. The study demonstrates that C60 increases both pro-inflammatory and anti-inflammatory cytokines, leading to significant IgA production in both mouse models and human peripheral blood mononuclear cells. This highlights its potential applications in enhancing mucosal immunity and suggests further exploration for therapeutic uses.
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关键证据
C60 promotes IgA production through functional modulation of intestinal B cells.
Significant increase in systemic IgA production observed in mice.
IL-6 and IL-10 produced by DCs are crucial for IgA upregulation.
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AI评分总结
Lactococcus lactis subsp. cremoris C60 is identified as a novel probiotic strain that enhances immunoglobulin A (IgA) production by modulating dendritic cells in the intestinal environment. The study demonstrates that C60 increases both pro-inflammatory and anti-inflammatory cytokines, leading to significant IgA production in both mouse models and human peripheral blood mononuclear cells. This highlights its potential applications in enhancing mucosal immunity and suggests further exploration for therapeutic uses.