Cardiomyocyte lncRNA Cpat maintains cardiac homeostasis and mitochondria function by targeting citrate synthase acetylation
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来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-10 23:37
摘要：
Cpat, a cardiomyocyte-enriched long non-coding RNA, plays a crucial role in maintaining cardiac homeostasis and mitochondrial function by regulating citrate synthase acetylation. Overexpression of Cpat in septic mouse models significantly improves cardiac function and reduces mortality rates. The study highlights the interaction between Cpat and mitochondrial proteins, revealing its potential as a therapeutic target for septic cardiomyopathy, emphasizing the importance of lncRNAs in metabolic regulation and cardiac health.
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关键证据
Cpat overexpression significantly improved cardiac functions and reduced mortality in septic mice.
Cpat regulates mitochondrial respiration and energy metabolism in cardiomyocytes.
The study identifies GCN5 as an acetyltransferase that Cpat inhibits, stabilizing mitochondrial enzyme complexes.
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AI评分总结
Cpat, a cardiomyocyte-enriched long non-coding RNA, plays a crucial role in maintaining cardiac homeostasis and mitochondrial function by regulating citrate synthase acetylation. Overexpression of Cpat in septic mouse models significantly improves cardiac function and reduces mortality rates. The study highlights the interaction between Cpat and mitochondrial proteins, revealing its potential as a therapeutic target for septic cardiomyopathy, emphasizing the importance of lncRNAs in metabolic regulation and cardiac health.