Nobiletin (NOB) nanoparticles ameliorate chronic paradoxical sleep deprivation (PSD)-induced cognitive deficits in rats
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来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-13 19:31
摘要：
Nobiletin (NOB) nanoparticles have been shown to alleviate cognitive deficits induced by chronic paradoxical sleep deprivation (PSD) in rats. The study reveals that NOB nanoparticles enhance cognitive performance by modulating microglial polarization and regulating the BMAL1/SIRT1/E2F1 axis. This research highlights the potential of NOB nanoparticles as a therapeutic strategy for cognitive impairments associated with sleep disorders, suggesting significant implications for future neuroprotective therapies.
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关键证据
NOB nanoparticles significantly improved cognitive performance in behavioral tests.
The treatment upregulated the expression of key proteins involved in cognitive function.
NOB nanoparticles shifted microglial polarization from pro-inflammatory to anti-inflammatory.
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AI评分总结
Nobiletin (NOB) nanoparticles have been shown to alleviate cognitive deficits induced by chronic paradoxical sleep deprivation (PSD) in rats. The study reveals that NOB nanoparticles enhance cognitive performance by modulating microglial polarization and regulating the BMAL1/SIRT1/E2F1 axis. This research highlights the potential of NOB nanoparticles as a therapeutic strategy for cognitive impairments associated with sleep disorders, suggesting significant implications for future neuroprotective therapies.