Central Zika virus infection causes hypothalamic inflammation and persistent insulin resistance in adult mice
8.5
来源：
Nature
关键字：
ML brain science
发布时间：
2025-10-13 19:32
摘要：
Zika virus (ZIKV) infection in adult mice results in significant hypothalamic inflammation and persistent insulin resistance, even after acute inflammation resolves. The study demonstrates that ZIKV invades the hypothalamus, triggering inflammatory responses that disrupt insulin signaling and alter neuropeptide expression critical for glucose homeostasis. Despite the resolution of inflammation, insulin resistance persists, suggesting a potential link between viral infections and long-term metabolic disorders such as obesity and type 2 diabetes. These findings underscore the importance of understanding the metabolic consequences of ZIKV neuroinvasion.
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关键证据
ZIKV infection leads to persistent hypothalamic insulin resistance.
Inflammatory responses were associated with impaired insulin signaling.
ZIKV replicates in the hypothalamus, causing long-term metabolic dysfunction.
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AI评分总结
Zika virus (ZIKV) infection in adult mice results in significant hypothalamic inflammation and persistent insulin resistance, even after acute inflammation resolves. The study demonstrates that ZIKV invades the hypothalamus, triggering inflammatory responses that disrupt insulin signaling and alter neuropeptide expression critical for glucose homeostasis. Despite the resolution of inflammation, insulin resistance persists, suggesting a potential link between viral infections and long-term metabolic disorders such as obesity and type 2 diabetes. These findings underscore the importance of understanding the metabolic consequences of ZIKV neuroinvasion.