MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death
8.0
来源：
Nature
关键字：
mRNA
发布时间：
2025-10-13 23:39
摘要：
MAPL (mitochondrial anchored protein ligase) plays a pivotal role in regulating pyroptotic cell death by mediating the release of mitochondrial DNA (mtDNA) from lysosomes. This process involves the activation of inflammatory pathways and has significant implications for diseases such as cancer and neurodegeneration. The study employs genome-wide CRISPR screening to elucidate the mechanisms by which MAPL influences immune signaling and cell death, highlighting its potential as a therapeutic target in biotechnology.
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关键证据
MAPL induces pyroptosis through an inflammatory pathway involving mitochondria and lysosomes.
MAPL overexpression promotes mitochondrial DNA trafficking in mitochondrial-derived vesicles to lysosomes.
Depletion of MAPL inhibits inflammatory cell death in primary macrophages.
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AI评分总结
MAPL (mitochondrial anchored protein ligase) plays a pivotal role in regulating pyroptotic cell death by mediating the release of mitochondrial DNA (mtDNA) from lysosomes. This process involves the activation of inflammatory pathways and has significant implications for diseases such as cancer and neurodegeneration. The study employs genome-wide CRISPR screening to elucidate the mechanisms by which MAPL influences immune signaling and cell death, highlighting its potential as a therapeutic target in biotechnology.